Enabling discovery by in-cell structural biology

Dr Julia Mahamid, EMBL Heidelberg.

Department of Chemistry, Pfizer Lecture Theatre.

Wednesday 15 November 2023, 10:30-11:30

A new phase in structural biology

Prof Dame Carol V Robinson, University of Oxford.

Department of Chemistry, Pfizer Lecture Theatre.

Wednesday 18 October 2023, 14:30-15:30

In-cell NMR for real-time studies of protein-ligand interactions in human cells

Dr. Enrico Luchinat, Department of Agricultural and Food Sciences, University of Bologna, and Magnetic Resonance Center (CERM), Florence, Italy.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 07 June 2023, 10:30-11:30

Disposable Chiral Plasmonics for Sensing

Dr. Affar S. Karimullah, School of Chemistry, University of Glasgow.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 24 May 2023, 10:30-11:30

Seeing memories through the looking glass: hippocampal circuit activity in mice performing spatial and working memory tasks

Prof. Simon R. Schultz, Centre for Neurotechnology, Imperial College London.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 10 May 2023, 10:30-11:30

Establishing a structure-function relationship between biomolecular condensates and protein degradation

Janet Kumita, Department of Pharmacology, University of Cambridge.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 29 March 2023, 10:30-11:30

Correlative imaging to resolve molecular structures in living tissues

Dr. Oxana Klementieva, Associate professor in molecular imaging, Department of Experimental Medicine, Lund University, Sweden.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 22 March 2023, 10:30-11:30

Mechanisms that Contribute to Proteostasis Collapse in Aging and Disease

Prof Richard I. Morimoto, Department of Molecular Biosciences, Rice Institute of Biomedical Research, Northwestern University, USA.

Department of Chemistry, Unilever Lecture Theatre.

Thursday 09 March 2023, 11:15-12:15

Modification of α-synuclein for inhibition of nucleation and elongation of amyloid fibrils

Prof Wolfgang Hoyer, Junior Professor of Chemical Biology of Protein Aggregation, Institute for Physical Biology, Heinrich-Heine-University Düsseldorf.

Department of Chemistry, Unilever Lecture Theatre.

Wednesday 08 February 2023, 10:30-11:30

Liquid-Liquid Crystalline Phase Separation of Amyloid Fibrils

Prof. Raffaele Mezzenga, ETH Zurich.

https://zoom.us/j/95370222402.

Wednesday 16 March 2022, 10:00-11:00

Uncovering the role of Alzheimer’s disease risk genes using stem cells and human brains

Prof Li-Huei Tsai, Massachusetts Institute of Technology.

https://zoom.us/j/99301642413.

Wednesday 19 January 2022, 16:00-17:00

Technology for Bioelectronic Medicine

Prof George Malliaras, University of Cambridge.

https://zoom.us/j/94174933868 .

Wednesday 19 January 2022, 10:30-11:30

From mad cows to mini brains

Cath Haig, NIH - NIAID - RML.

https://zoom.us/j/96577382505.

Wednesday 01 December 2021, 16:00-17:00

Photopharmacology: Towards Light-Controlled Therapy

Prof. Wiktor Szymanski, University Medical Center Groningen.

https://zoom.us/j/95320855185.

Wednesday 24 November 2021, 10:00-11:00

How to discover prodromal Parkinson's disease and why

Wolfgang Oertel, Philips University of Marburg.

https://zoom.us/j/92675147881.

Wednesday 17 November 2021, 10:30-11:30

Title to be confirmed

Macr Diamond, University of Texas Southwestern Medical Center.

https://zoom.us/j/92675147881.

Tuesday 19 October 2021, 17:00-18:00

ApoE, Ab and Alzheimer’s disease: From test tube to transgenic mice

Mary Jo LaDu, University of Illinois at Chicago.

https://zoom.us/j/92564124601.

Wednesday 13 October 2021, 16:00-17:00

The landscape of amyloid misfolding

Prof. Jeremy Schmit (Kansas State University).

https://zoom.us/j/99567836121.

Wednesday 21 July 2021, 10:30-11:30

Peptide and metabolite self-assembly: Physiology, Pathology, and Nanotechnology

Prof. Ehud Gazit, Tel Aviv University.

https://zoom.us/j/92040905282.

Wednesday 07 July 2021, 10:30-11:30

Phase separation as an organizing principle in biology and disease

Simon Alberti, Technische Universität Dresden.

https://zoom.us/j/98205706861?pwd=MitmZ2pqVHNKWmdwMWlVUkpWZkNDdz09.

Wednesday 09 June 2021, 10:30-11:30

Functional Protein Fibrils in the Fight Against Pathogens

Prof. Meytal Landau, Technion-Israel Institute of Technology.

https://zoom.us/j/96842517234.

Wednesday 02 June 2021, 10:30-11:30

Probing proteome foldedness and conformational changes under proteostasis stresses

Prof. Danny Hatters, University of Melbourne.

https://zoom.us/j/92985851709.

Wednesday 26 May 2021, 09:00-10:00

Single molecule electrometry: "far-field" electrostatic fingerprints of molecular 3D conformation and shape

Professor Madhavi Krishnan ( University of Oxford).

https://zoom.us/j/95836951805.

Friday 21 May 2021, 10:30-11:30

Cellular Communication via Adhesion

Prof. Demet Araç, University of Chicago.

https://zoom.us/j/99781367340.

Wednesday 19 May 2021, 16:00-17:00

Cellular Organization Through Liquid-Liquid Phase Separation

Prof. Michael Rosen, Department of Biophysics, University of Texas .

https://zoom.us/j/97334125524.

Wednesday 12 May 2021, 16:00-17:00

Whole-brain imaging of mating behavior in C. elegans

Prof. Aravinthan Samuel, Harvard University.

https://zoom.us/j/97805738886 .

Friday 07 May 2021, 16:00-17:00

Phase separation as an organizing principle in biology and disease

Speaker to be confirmed.

https://zoom.us/j/99781367340.

Thursday 06 May 2021, 16:00-17:00

Gating Mechanisms and drug modulation in Pentameric Ligand-gated Ion Channels: Insights from Cryo-EM

Prof. Sudha Chakrapani, Case Western Reserve University.

https://zoom.us/j/94961379063.

Wednesday 05 May 2021, 16:00-17:00

The switch from choice to commitment: an example from HIV

Dr. Maike Hansen, Radboud University Nijmegen.

https://zoom.us/j/92521025039.

Wednesday 28 April 2021, 10:30-11:30

Deciphering the role of post-translational modifications in p53 regulation with protein semisynthesis

Dr. Manuel Muller .

https://zoom.us/j/95477079823.

Wednesday 21 April 2021, 10:30-11:30

Cell morphogenesis across scales, from molecules to forces

Prof. Ewa Paluch Department of Physiology, Development and Neuroscience, University of Cambridge.

https://zoom.us/j/92582731025.

Wednesday 14 April 2021, 10:30-11:30

Self-entangled misfolded structures are the molecular bridge connecting synonymous mutations to long-timescale changes in protein structure and function

Ed O'Brien, Pennsylvania State University.

https://zoom.us/j/92635473991.

Wednesday 31 March 2021, 16:00-17:00

Stabilization of Protein-Protein Interactions; from biophysical concept to medicinal chemistry application

Prof. Luc Brunsveld, Eindhoven University of Technology .

https://zoom.us/j/97842548910.

Wednesday 24 March 2021, 10:30-11:30

Glutamate receptors: from single molecules to physiology

Prof. Vasanthi Jayaraman, University of Texas Health Science Center.

https://zoom.us/j/99203574537.

Wednesday 17 March 2021, 16:00-17:00

A detailed look at tail-anchored membrane protein targeting - from metazoans to plants to protists

Prof. William Clemons, Caltech.

https://zoom.us/j/98085179345.

Wednesday 10 March 2021, 16:00-17:00

We were unable to deliver your parcel: Tumour biophysics and drug delivery

Sally Peyman, University of Leeds.

https://zoom.us/j/94270162364?pwd=VTBVMGhUTEttNHlkaGRtcFF2TzdUUT09.

Wednesday 03 March 2021, 10:30-11:30

Probing intracellular physicochemical environments at the nanoscale, one molecule at a time

Ke Xu, UC-Berkeley.

https://zoom.us/j/99827103152?pwd=K0ZGZk9xSzBsSHFRbDRwZTF4dExiQT09.

Wednesday 24 February 2021, 16:00-17:00

Conformational control: From single molecules to biotechnologies

Prof. Taekjip Ha, Johns Hopkins University .

https://zoom.us/j/97411702169?pwd=c3JEeVBWemdQb3FHeGc0Smk3M2ZiQT09.

Wednesday 17 February 2021, 16:00-17:00

Molecular Biology of Prion Infections

Prof. Adriano Aguzzi, University hospital of Zurich.

https://zoom.us/j/99760374933?pwd=cXlRUVBabWpCUWZ4NHRGWnRmLzV3dz09.

Wednesday 10 February 2021, 10:30-11:30

Models of neurological disease

Meeting ID: 923 1614 3946 Passcode: 186434

Prof. Roger D Kamm.

https://zoom.us/j/92316143946?pwd=RmFpcnlrNWkrUldWbzZRazhxRjM2QT09.

Wednesday 03 February 2021, 16:00-17:00

Fragments of stories: biophysics, chemical biology and drug discovery

Rod Hubbard, University of York and Vernalis.

https://zoom.us/j/98208866632?pwd=RW1QeWtUNzViZTRiVlBGU2d0b1Evdz09.

Thursday 28 January 2021, 10:30-11:30

Dissipative systems showing signs of life

Prof. W.T.S. Huck, Institute for Molecules and Materials, Radboud University, Nijmegen, the Netherlands.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 04 March 2020, 10:30-11:30

Physical phenotyping of cells in biology and medicine

Prof. Jochen Guck, Director, Max Planck Institute for the Science of Light.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 26 February 2020, 10:30-11:30

Protein misfolding in Alzheimer’s disease

Prof. Louise Serpell, University of Sussex, UK.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 19 February 2020, 10:30-11:30

Evolution of Antibiotic Resistance: from the Lab to the Clinic and back

Prof. Nathalie Q. Balaban, The Hebrew University of Jerusalem.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 12 February 2020, 10:30-11:30

Dynamic supramolecular materials for medicine

Prof Dr Tanja Weil.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 05 February 2020, 10:30-11:30

Higher order from high disorder: DNA condensation by linker histone tails

Katherine Stott (Department of Biochemistry).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 29 January 2020, 10:30-11:30

Functional amyloid in bacteria

Professor Daniel E. Otzen, Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, DK.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Friday 24 January 2020, 11:00-12:00

Molecular chaperones in protein folding and quality control

Prof. Dr. F. Ulrich Hartl ( Max Planck Institute of Biochemistry).

Department of Chemistry, Cambridge, Wolfson Lecture Theatre.

Thursday 23 January 2020, 16:00-17:00

Artificial Cells and Cellular Bionics

Prof. Oscar Ces, Department of Chemistry, Imperial College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 04 December 2019, 10:30-11:30

Autophagy and neurodegeneration

Professor David Rubinsztein ( CIMR).

Department of Chemistry, Cambridge, Todd Hamied Room.

Wednesday 27 November 2019, 10:30-11:30

Emergence of life-like properties in coacervate droplets

Evan Spruijt, Radboud University, the Netherlands.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 November 2019, 10:30-11:30

Mechanism in Collective Organizations of Living and Synthetic Cells

Professor Joachim P. Spatz, Max Planck Institute for Medical Research & Heidelberg University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Monday 11 November 2019, 11:00-12:00

New tools for using single-molecule spectroscopy to elucidate biophysical behavior

Professor Randall Goldsmith, University of Wisconsin Madison.

Department of Chemistry, Cambridge, Todd Hamied Room.

Wednesday 16 October 2019, 11:00-12:00

Detection of Alzheimer’s Protein Biomarker Clusterin using novel Graphene Biosensors

Shakil A. Awan, Wolfson Nanomaterials & Devices Laboratory, School of Computing, Electronics and Mathematics, University of Plymouth.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Thursday 20 June 2019, 11:00-12:00

Materials Chemistry to Mimic Living Matter

Prof. Samuel Stupp, Simpson Querrey Institute for Bio-Inspired Science and Technologies Northwestern University.

Department of Chemistry, Cambridge, Wolfson Lecture Theatre.

Wednesday 12 June 2019, 10:30-11:30

Selective inhibition of phosphatases to boost protein quality control : A possible treatment for degenerative diseases

Anne Bertolotti, MRC Laboratory of Molecular Biology.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 05 June 2019, 10:30-11:30

Determination of protein structure and dynamics with integrative approaches

Massimiliano Bonomi, Structural Bioinformatics Unit, Institut Pasteur.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 29 May 2019, 10:30-11:30

Protein phase transition: from biology towards new protein materials

Paolo Arosio, Dept of Chemistry and Applied Biosciences, ETH Zurich.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 22 May 2019, 10:30-11:30

Protein dynamics and molecular recognition

Carlo Camilloni, Department of Biosciences, University of Milan.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 15 May 2019, 10:30-11:30

Sustaining Life with Genes and Proteins Designed ‘From Scratch’

Professor Michael Hecht, Department of Chemistry, Princeton University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 08 May 2019, 10:30-11:30

Deep Proteomes, iPS cells & Data Mountains

Prof. Angus Lamond, Centre for Gene Regulation and Expression, University of Dundee.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 01 May 2019, 10:30-11:30

Proteostasis function and disfunction: the folding machines that maintain proteome health

Judith Frydman, Stanford University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Friday 26 April 2019, 11:00-12:00

The ribosome – from far past to near future

Ada Yonath, Structural Biology Department, Weizmann Institute of Science.

Bristol-Myers-Squibb Lecture Theatre, Department of Chemistry, Lensfield Road, Cambridge.

Wednesday 17 April 2019, 10:30-11:30

Recent progress in electron cryomicroscopy

Richard Henderson, MRC Laboratory of Molecular Biology.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 03 April 2019, 10:30-11:30

Modulating Disease-relevant Tau Oligomeric Strains by Small Molecules

Filippa Lo Cascio, University of Texas Medical Branch.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Thursday 21 March 2019, 10:30-11:30

Investigating the propagation and spreading of protein aggregates in C. elegans

Carmen Nussbaum-Krammer, Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 March 2019, 10:30-11:30

Material properties of functional amyloids

Dr Ulyana Shimanovich, Department of Materials and Interfaces, Weitzmann Institute of Science.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 13 March 2019, 10:30-11:30

Prion propagation and its wider relevance in neurodegeneration

John Collinge, Department of Neurodegenerative Disease, University College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 06 March 2019, 10:30-11:30

A super-resolved look at synthetic nanomaterials

Lorenzo Albertazzi, Institute for Bioengineering of Catalonia (IBEC).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 February 2019, 10:30-11:30

Aggregation of tau and alpha-synuclein: towards a therapeutic target in neurodegenerative diseases

Maria Grazia Spillantini, Department of Clinical Neurosciences, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 06 February 2019, 10:30-11:30

Using protein side-chain dynamics to probe enzymatic function and regulation

Professor Flemming Hansen, Department of Structural & Molecular Biology, University College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 30 January 2019, 10:30-11:30

Engineered proteins as tools for assembly of functional structures and materials

Aitziber L. Cortajarena, CIC biomaGUNE.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Friday 25 January 2019, 11:15-12:15

ARPP21 mutations reveal the role of RNA granule dysfunction in ALS and FTD

Christopher E Shaw, King's College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 16 January 2019, 10:00-11:00

Understanding somatic and germline cancer mutations at the structural level using biomolecular simulations and graph theory

Professor Elena Papaleo.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 05 December 2018, 10:30-11:30

The role of α-synuclein at the pre-synapse

Dr. Gabriele Kaminski Schierle, Dept. of Chemical Engineering and Biotechnology, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 21 November 2018, 10:30-11:30

Molecular Studies in Vascular Dementia

Atticus Hainsworth, St George's University of London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 07 November 2018, 10:30-11:30

Cellular responses to DNA damage: mechanistic insights and therapeutic applications

Prof. Steve Jackson, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 31 October 2018, 10:30-11:30

Dr Jekyll and Mr Hyde: RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

Prof. Annalisa Pastore.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 24 October 2018, 10:30-11:30

On the structure-function uncertainties of proteins

Prof. Monika Fuxreiter, Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Thursday 18 October 2018, 11:00-12:00

Tuning protein biogenesis at the level of translation: probing dimensionality beyond the linear sequence of mRNA

Prof. Zoya Ignatova, Institute of Biochem. & Mol. Biol., Univ. of Hamburg, Germany.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 17 October 2018, 10:30-11:30

Neurons Put Out the Trash: A Novel Facet of Proteostasis and Mitochondrial Quality Control

Prof. Monica Driscoll, Rutgers University, Department of Molecular Biology and Biochemistry, Piscataway, NJ, USA.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Monday 15 October 2018, 11:00-12:00

Protein Misfolding Diseases. The Structural Determinants of Protein Misfolded Oligomers Responsible for Toxicity and the Mechanism through which Toxicity is Mediated

Prof. Fabrizio Chiti, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Section of Biochemistry, University of Florence, Italy.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 10 October 2018, 10:30-11:30

Cell Uptake and Trafficking: from amyloid proteins to drug delivery vehicles

Prof. Elin K. Esbjörner, Department of Biology and Biological Engineering, Chalmers University of Technology, Sweden.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Friday 05 October 2018, 14:00-15:00

Title to be confirmed

Prof Ralf Jungmann, Max Planck Institute of Biochemistry.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 04 July 2018, 10:30-11:30

[CANCELLED] Power and benefit of harnessing of phosphatase for the treatment of neurodegenerative diseases.

Anne Bertolotti, MRC Laboratory of Molecular Biology.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 27 June 2018, 10:30-11:30

Binding without folding: Extreme disorder and dynamics in a high-affinity protein complex

Ben Schuler, University of Zurich, Department of Biochemistry and Department of Physics, Zurich, Switzerland.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 June 2018, 10:30-11:30

Microfluidic methods to study single cells and peptide-membrane interactions

Prof. Petra S. Dittrich, Department of Biosystems Science and Engineering, ETH Zurich.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 06 June 2018, 10:30-11:30

PrP post-translational modifications determine prion disease outcome

Christina J. Sigurdson, D.V.M., Ph.D., Department of Pathology, UC San Diego.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 30 May 2018, 10:30-11:30

Weighing single molecules with light

Philipp Kukura, Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford.

Department of Chemistry, Cambridge, Pfizer Lecture Theatre.

Thursday 17 May 2018, 15:00-16:00

Democratising high-quality live-cell super-resolution microscopy enabled by open-source analytics in ImageJ

Ricardo Henriques, MRC-Laboratory for Molecular Cell Biology, University College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 25 April 2018, 10:30-11:30

Encapsulating Matter, from inert to alive: design and applications.

Professor Jérôme Bibette, ESPCI, Laboratoire Colloïdes et Matériaux divisés.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Thursday 05 April 2018, 10:30-11:30

Cancelled

Speaker to be confirmed.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 21 March 2018, 10:30-11:30

NMR atomic-resolution structures of amyloids

Beat H. Meier (Laboratory of Physical Chemistry, ETH Zürich).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 14 March 2018, 10:30-11:30

Developing drugs for neurodegeneration and other diseases in academia, industry and in-between

John Skidmore, Alzheimer’s Research UK Cambridge Drug Discovery Institute.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 21 February 2018, 10:30-11:30

Biologically inspired de novo protein structure prediction

Professor Charlotte Deane, Professor of Structural Bioinformatics & Head of Department, Department of Statistics University of Oxford.

Department of Chemistry, Cambridge, Pfizer lecture theatre.

Wednesday 17 January 2018, 10:30-11:30

New insights into protein misfolding in Alzheimer's and Parkinson's diseases using in vivo systems

Professor Dennis Selkoe, Harvard Medical School, Center for Neurologic Diseases, Brigham & Women’s Hospital.

Department of Chemistry, Cambridge, Pfizer lecture theatre.

Wednesday 13 December 2017, 11:00-12:00

Kinetic Insights into amyloid-β metal ion interactions and implications for AD.

Dr Liming Ying, Imperial College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 06 December 2017, 10:30-11:30

Learning from Nature to Form New Organic Materials for Tissue Regeneration

Dr. Lihi Adler-Abramovich, Tel Aviv University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 29 November 2017, 10:30-11:30

Microfluidic Single-Cell Manipulation and Analysis

Dr. Stefano Pagliara, University of Exeter.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 22 November 2017, 10:30-11:30

"A TREMendous mechanism for Alzheimer's Disease: therapeutic insights"

Dr Damian Crowther, Neuroscience, IMED Biotech Unit, AstraZeneca.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 15 November 2017, 10:30-11:30

Evolution and assembly of protein complexes

Dr Sarah Teichmann, Sanger Institute, Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 08 November 2017, 10:30-11:30

Deep Learning in Chemistry

Dr Richard Dybowski, Department of Veterinary Medicine, Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 25 October 2017, 10:30-11:30

Microglia eating neurons and TREM2:Abeta interactions in neurodegeneration

Prof. Guy Brown, Department of Biochemistry, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 18 October 2017, 10:30-11:30

Redox-dependent modulation of haemostasis and vascular function by amyloid peptide beta: a new interpretation of the vascular component of dementia.

Dr Giordano Pula, University of Exeter Medical School.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 11 October 2017, 10:30-11:30

Pre-degenerative deficits in dopamine transmission in an alpha-synuclein mouse model of Parkinson’s disease: the role of lipids and the dopamine transporter

Sarah Threlfell, Senior Research Fellow, Dept. Physiology, Anatomy and Genetics, University of Oxford, Oxford Parkinson’s Disease Centre.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 27 September 2017, 12:30-13:30

Cryo-EM structures of Tau filaments from Alzheimer's disease brains

Anthony W.P. Fitzpatrick.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 30 August 2017, 10:30-11:30

Biomolecular self-assemblies by solid-state NMR: functional amyloids and bacterial filaments

Dr Birgit Habenstein, CBMN UMR5248 CNRS, Institut de Biologie & Chimie des Membranes & Nanoobjets.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 19 July 2017, 10:30-11:30

Designing drugs on an intrinsically disordered protein involved in pancreatic cancer

Professor José Luis Neira, Instituto de Biologia Molecular y Celular, Universidad Miguel Hernández, Elche (Alicante), Spain.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 05 July 2017, 10:30-11:30

Mutant HTT aggregation and conformers: what we know and what we don’t know

Erich E. Wanker, Head Neuroproteomics and Molecular Mechanisms of Neurodegenerative Diseases, Max Delbrueck Center for Molecular Medicine (MDC) Berlin-Buch.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 21 June 2017, 10:30-11:30

LILBID-mass spectrometry: interrogating non-covalent complexes

Nina Morgner, nstitute of physical and theoretical chemistry, Goethe University Frankfurt.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 07 June 2017, 10:30-11:30

Molecular evolution of macrocyclic rescuers of disease-associated protein misfolding

Dr. Georgios Skretas, Research Assistant Professor, Institute of Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Athens, Greece.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 31 May 2017, 10:30-11:30

NMR spectroscopy to study dynamics with applications to immunology and neurodegeneration

Professor Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Göttingen.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 17 May 2017, 10:30-11:30

Amyloids from the origin to the end of life

Professor Roland Riek, ETH Zurich.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 10 May 2017, 10:30-11:30

Switching to the dark side: Repositioning of Polyglutamine Repeat Promotes Amyloid Fibril Formation by the Model Protein, β-Lactamase BlaP

Dr Mireille Dumoulin, University of Liege.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 03 May 2017, 10:30-11:30

Dynamics and thermodynamics of ligand binding to galectin-3

Professor Mikael Akke, Lund University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 26 April 2017, 10:30-11:30

Biophysical Seminar Series 2016/17

Amyloid oligomers : precursors, competitors or inhibitors of fibril formation

Professor Martin Muschol, Dept. of Physics, University of South Florida.

Unilever Lecture Theatre, Department of Chemistry.

Wednesday 19 April 2017, 10:30-11:30

Fuzziness in function and evolution of proteins

Dr Monika Fuxreiter, MTA-DE Momentum Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 22 March 2017, 10:30-11:30

Pathogenic vs. Reversible Amyloid & Inhibition of Aggregation

Prof David Eisenberg, Howard Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry & Biochemistry, UCLA, Los Angeles, California, USA.

Department of Chemistry, Cambridge, Pfizer lecture theatre.

Wednesday 01 March 2017, 11:00-12:00

Disentangling Polydispersity in Biological Systems by SAXS

Pau Bernadó, Centre de Biochimie Structurale (CBS).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 22 February 2017, 10:30-11:30

New insights into protein misfolding in Alzheimer’s and Parkinson’s diseases using in vivo systems

Prof Dennis Selkoe, Harvard Medical School and Brigham and Women's Hospital.

Department of Chemistry, Cambridge, Pfizer lecture theatre.

Friday 17 February 2017, 14:00-15:00

From the bush to the bench: a short-lived african fish reveals novel aspects of the genetic control of aging

Alessandro Cellerino, Scuola Normale Superiore, Pisa, Italy and Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 18 January 2017, 10:30-11:30

A combined experimental and computational approach to study protein aggregation

Professor Salvador Ventura, UAB Barcelona.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 14 December 2016, 10:30-11:30

Insights into unfolded protein states and GPCR function by solution NMR

Prof. Dr. Stephan Grzesiek, University of Basel.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 07 December 2016, 10:30-11:30

Molecular Chaperone Functions in Protein Folding and Quality Control

Prof. Dr. F. Ulrich Hartl, Max Planck Institute of Biochemistry.

Department of Chemistry (Pfizer lecture theatre).

Wednesday 16 November 2016, 11:00-12:00

Polymers through protein pores: single-molecule experiments with nucleic acids, polypeptides and polysaccharides

Professor Hagan Bayley, Department of Chemistry, University of Oxford.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 09 November 2016, 10:30-11:30

Beta-hairpin motifs of amyloidogenic IDP

Dr. Wolfgang Hoyer, University of Dusseldorf.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 26 October 2016, 10:30-11:30

Designing drugs on an intrinsically disordered protein involved in pancreatic cancer

All welcome

Jose L Neira Instituto de Biologia Molecular y Celular. Universidad Miguel Hernandez, Elche (Alicante) Spain.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 24 August 2016, 10:30-11:30

Cytoplasm, nucleus and endoplasmic reticulum differ in their responses towards toxic protein aggregation

All welcome

Dr. Mark S. Hipp, Max Planck Institute of Biochemistry.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 08 June 2016, 10:30-11:30

The cutting edge of Alzheimer’s disease research

All welcome

Prof. Bart De Strooper, University of Leuven and University College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 01 June 2016, 10:30-11:30

The properties of nano-scale amyloid fibril fragments in vitro and in vivo

All welcome

Dr Wei-Feng Xue, School of Biosciences, University of Kent.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 25 May 2016, 10:30-11:30

Expanding the universe of protein structure and function by design

Dek Woolfson Schools of Chemistry and Biochemistry, & BrisSynBio University of Bristol, UK.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 18 May 2016, 10:30-11:30

Order disorder transitions in the regulation of transcription: biomedical implications

Xavier Salvatella, IRB Barcelona.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 11 May 2016, 10:30-11:30

α-Synuclein: amyloid inclusions and supra-fibrillar structures

Prof. Mireille Claessens (University of Twente, The Netherlands).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 04 May 2016, 10:30-11:30

** CANCELLED** Functional versatility and regulation of proteins with intrinsically disordered regions

Cancelled

M. Madan Babu, MRC Laboratory of Molecular Biology, Cambridge, UK.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 27 April 2016, 10:30-11:30

Enhancing nanopore sensing with DNA nanotechnology

All welcome

Ulrich F. Keyser, Cavendish Laboratory, University of Cambridge .

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 April 2016, 10:30-11:30

The self-assembly, functionalization and cellular interactions of short amyloid fibril forming peptides

All welcome

Sally Gras, The University of Melbourne.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Tuesday 19 April 2016, 10:30-12:00

Diamond B23 beamline for synchrotron radiation circular dichroism (SRCD) and applications to time resolved CD with micro-devices, spatially resolved CD of thin films, protein-ligand binding interactions and high throughput CD with 96-well plates

All welcome

Giuliano Siligardi - Diamond Light Source Ltd.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 13 April 2016, 11:00-12:00

Novel insights into the molecular mechanism of α-synuclein amyloid formation - The effects of intrinsic and extrinsic factors

Dr Celine Galvagnion, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 16 March 2016, 10:30-11:30

Structural Analysis of Amyloid-like Protein Fibrillation

All welcome

Bente Vestergaard, Department of Drug Design and Pharmacology, University of Copenhagen.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 09 March 2016, 10:30-11:30

Electron microscopy studies of protein aggregation and disaggregation

All welcome

Helen Saibil ISMB, Birkbeck College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 02 March 2016, 10:30-11:30

Fates of mitochondrial proteins.

Prof. Agnieszka Chacinska.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 24 February 2016, 10:30-11:30

The role of extrinsic and intrinsic factors in amyloid β peptide aggregation

Prof. Sara S. Linse, Lund University.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 17 February 2016, 10:30-11:30

Rational design of protein aggregation

Prof. Frederic Rousseau, VIB (Belgium).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 10 February 2016, 10:30-11:30

Understanding the neuronal control of ageing and proteostasis

Dr. Rebecca Taylor, MRC Laboratory of Molecular Biology.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 03 February 2016, 10:30-11:30

Chaperoning single proteins

All welcome

Prof. Sander Tans, AMOLF.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 27 January 2016, 10:30-11:30

"Acid sensing and sensory innervation: from molecules to mammals”

All welcome

Dr. Ewan St. John Smith, Department of Pharmacology, University of Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 20 January 2016, 10:30-11:30

How cryo-EM is revolutionising structural biology

Dr. Sjors Scheres, MRC Laboratory of Molecular Biology, Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 13 January 2016, 10:30-11:30

Non-covalent Peptide Assembly: The latest Results

All welcome

Mike Bowers, UC Santa Barbara.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Thursday 10 December 2015, 16:00-17:00

Membrane protein folding, the regulation of membrane function and construction of synthetic membrane modules

Prof. Paula Booth, King's College London.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 02 December 2015, 10:30-11:30

The mechanical control of neuronal development

Dr Kristian Franze, University of Cambridge (PDN).

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 25 November 2015, 10:30-11:30

Microtechnologies for biomolecular complex analysis and cryo-microscopy

All welcome

Dr Thomas Burg, Max Planck Institute for Biophysical Chemistry.

Department of Chemistry, Cambridge, Wolfson Lecture Theatre.

Wednesday 18 November 2015, 15:00-16:00

Pathways of protein quality control in the cytosol

Dr. Ramanujan Hegde, LMB Cambridge.

Department of Chemistry, Cambridge, Unilever lecture theatre.

Wednesday 04 November 2015, 10:30-11:30

Controlling Protein Damage

All welcome

Dr. Stefan Rüdiger, Utrecht University.

Department of Chemistry, Cambridge, Unilever lecture theater.

Wednesday 28 October 2015, 10:30-11:30

Naturally occurring micro reactors: phase separation as a regulated strategy for compartmentalisation in cells.

Everyone is welcome

Dr. Andrew Baldwin, Oxford University.

Department of Chemistry, Cambridge, Unilever lecture theater.

Wednesday 21 October 2015, 10:30-11:30

Looking at proteins in live cells with atomic resolution: From Science Fiction to Science Reality

Everyone is welcome

Dr. Phil Selenko, FMP Berlin.

Department of Chemistry, Cambridge, Unilever lecture theater.

Wednesday 14 October 2015, 10:30-11:30

Proteome homeostasis and protein aggregation in ALS

Everyone is welcome

Dr. Justin Yerbury, University of Wollongong.

Department of Chemistry, Cambridge, Unilever lecture theater.

Wednesday 07 October 2015, 10:30-11:30