“Translational applications of human brain charts: from clinical to population neuroscience”

The talk is in-person only and a recording is not available.

Dr Richard Bethlehem, University of Cambridge.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 11 April 2024, 12:00-13:00

“Tools for studying variation in the dark genome”

Dr Michael Eberle, PacBio Computational Biology Group.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 28 March 2024, 12:00-13:00

“The all ‘A’s: ageing, Alzheimer, autophagy, AI, and an ‘A’ compound in brain health and longevity”

Please note that the talk this week is on Monday instead of the usual Thursday

Dr Evandro Fei Fang, University of Oslo.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Monday 18 March 2024, 12:00-13:00

“Atomic pathology of neurodegenerative diseases by cryo-EM of amyloid filaments”

TIME CHANGE Please note this talk is from 2pm to 3pm

Benjamin Ryskeldi-Falcon, MRC Laboratory of Molecular Biology, University of Cambridge.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 07 March 2024, 14:00-15:00

“Biomarkers for Alzheimer’s disease in clinical routine - a pretty Swedish perspective”

The talk is in-person only and a recording is not available.

Prof Michael Schöll, University of Gothenburg.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 29 February 2024, 12:00-13:00

“Enhancing Insight into Neurodegenerative Disease-Associated Genes via Long-Read RNA-Sequencing”

Dr Emil Gustavsson, University College London.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 22 February 2024, 12:00-13:00

“Complement in Alzheimer’s Disease”

Dr Wioleta Zelek, Cardiff University.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 01 February 2024, 12:00-13:00

“Ambient Mass Spectrometry in Neuroscience: From spatial biology to neurosurgery”

Prof Zoltan Takats, Imperial College London.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 25 January 2024, 12:00-13:00

"The Importance of Behavioural Bioassays in Neuroscience"

Prof Richard Brown, Dalhousie University, Canada .

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Friday 19 January 2024, 13:00-14:00

“Are Toll-like receptors and inflammasomes therapeutic targets for neuroinflammation?”

Prof Clare Bryant, University of Cambridge.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 11 January 2024, 12:00-13:00

“Translational applications of human brain charts: from clinical to population neuroscience”

Dr Richard Bethlehem, University of Cambridge.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 09 November 2023, 12:00-13:00

“Unexpected physiologic role of alpha-synuclein Serine-129 phosphorylation”

Professor Subhojit Roy, University of California, San Diego.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Tuesday 10 October 2023, 16:30-17:30

“Thoughts on the interaction of different memory systems: evidence from semantic dementia”

Professor Karalyn Patterson, University of Cambridge .

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Thursday 05 October 2023, 12:00-13:00

“Energy Matters: Programming axonal mitochondrial maintenance and bioenergetics to power neural regeneration”

Dr Zu-Hang Sheng, NINDS, NIH.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Tuesday 11 July 2023, 16:00-17:00

“Energy Matters: Programming axonal mitochondrial maintenance and bioenergetics to power neural regeneration”

Dr Zu-Hang Sheng, NINDS, NIH.

Seminar Room, John van Geest Centre for Brain Repair, Forvie Site.

Tuesday 11 July 2023, 16:00-17:00

“Molecular and genetic mechanisms of neuron-glia interactions”

Professor Kelly Monk, Vollum Institute, Oregon Health & Science University.

Herchel Smith Building Seminar Room.

Thursday 22 June 2023, 12:00-13:00

"Autophagy and neurodegeneration"

Professor David Rubinsztein, Department of Medical Genetics, University of Cambridge.

Hybrid seminar: Clinical School Seminar Room 14 & on Zoom (see Abstract for link).

Thursday 02 February 2023, 12:00-13:00

"Leveraging transcriptomic maps to navigate human brain diseases"

Dr Mina Ryten, Professor of Clinical Genetics, UCL Great Ormond Street Institute of Child Health.

Hybrid seminar: Clinical School Seminar Room 3 & on Zoom (see Abstract for link).

Thursday 26 January 2023, 12:00-13:00

"Neuronal and glial responses to the absence of microglia"

Professor Josef Priller, University of Edinburgh, DRI & Technical University Munich.

Hybrid seminar: Clinical School Seminar Room 11 & on Zoom (see Abstract for link).

Thursday 19 January 2023, 12:00-13:00

"White matter in dementia; from lesions to plasticity"

Dr Ragnhildur Thora Karadottir, University of Cambridge.

Hybrid seminar: Clinical School Seminar Room 2 & on Zoom (see Abstract for link).

Thursday 12 January 2023, 12:00-13:00

“Gene Therapy and beyond – hopes and challenges in therapy development for neurological disorders”

Dr Kathrin Meyer, Ohio State University.

MRC MBU, Sackler Lecture Theatre, The Keith Peters Building, CB2 0XY.

Monday 10 October 2022, 13:00-14:00

“Axoptosis: Mechanisms for coordinating axonal degeneration”

Professor Leonard A. Levin, McGill University.

Zoom (link will be given in Abstract).

Thursday 30 June 2022, 12:00-13:00

“In vivo assessment of synaptic loss in non-AD tauopathies”

Dr Negin Holland, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 23 June 2022, 12:00-13:00

“Inducing mtDNA alterations in mouse dopaminergic neurons to study if and how they contribute to Parkinsons disease like phenotype”

Professor Rudolf Wiesner, University of Cologne.

Zoom (link will be given in Abstract).

Thursday 16 June 2022, 12:00-13:00

“Sickness behaviour and depression: an updated model of peripheral central immune interactions”

Professor Federico Turkheimer, King's College London.

Zoom (link will be given in Abstract).

Thursday 09 June 2022, 12:00-13:00

"The prohibitin proteins in myelination"

Dr Emma Wilson, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 26 May 2022, 12:00-13:00

"HUNTINGTON’S DISEASE- Where has our research taken us to date?"

Professor Roger Barker, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 19 May 2022, 12:00-13:00

“Can we block axon degeneration in disease?”

Dr Andrea Loreto, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 05 May 2022, 12:00-13:00

“Myelinated axon formation, health and function”

Professor David Lyons, University of Edinburgh.

Zoom (link will be given in Abstract).

Thursday 07 April 2022, 12:00-13:00

“Myelin's highway to the axon and implications for axonal support”

Professor Julia Edgar, University of Glasgow.

Zoom (link will be given in Abstract).

Thursday 24 March 2022, 12:00-13:00

“Functional transcriptomics in neurodegenerative disorders”

Dr Roberto Simone, Queen Square Institute of Neurology, UCL.

Zoom (link will be given in Abstract).

Thursday 17 March 2022, 12:00-13:00

“Beyond proteinopathies, in vivo clinical markers for inflammation and synaptic loss in frontotemporal lobar degeneration”

Dr Maura Malpetti, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 10 March 2022, 12:00-13:00

Structure-function of the Endoplasmic Reticulum and neuronal de/regeneration

Dr Edward Avezov, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 24 February 2022, 12:00-13:00

“Presynaptic dysfunction in neurodevelopmental disorders”

Professor Mike Cousin, University of Edinburgh.

Zoom (link will be given in Abstract).

Thursday 17 February 2022, 12:00-13:00

“Targeting astrocytes to protect the brain in Vascular Cognitive Impairment”

Dr Jill Fowler, University of Edinburgh.

Zoom (link will be given in Abstract).

Thursday 10 February 2022, 12:00-13:00

"Fumarate hydratase and cancer: a paradigm of oncometabolism”

Professor Christian Frezza, University Hospital Cologne.

Zoom (link will be given in Abstract).

Thursday 03 February 2022, 12:00-13:00

"Targeting axon transport to support axon regeneration in the adult CNS”

Dr Richard Eva, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 27 January 2022, 12:00-13:00

"Can we improve human nerve regeneration?”

Dr Peter Arthur-Farraj, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 20 January 2022, 12:00-13:00

“Distinctive gene expression distribution in microglia and astrocytes in relation to distance from plaques in NLF knockin mice, where differences are undetectable in bulk RNAseq.”

Introduction by Dr Bryan Serrels, NanoString

Professor Frances Edwards, University College London.

Zoom (link will be given in Abstract).

Thursday 02 December 2021, 12:00-13:00

"Prion diseases: risk factors, experimental treatments, and ways to improve care"

Professor Simon Mead, University College London.

Zoom (link will be given in Abstract).

Thursday 25 November 2021, 12:00-13:00

"What did organoids do for us? - mechanistic & therapeutic discoveries at single cell resolution in ALS/FTD”

Dr Andras Lakatos, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 18 November 2021, 12:00-13:00

The Interplay between Local Protein Synthesis and Axon/NMJ Maintenance and Degeneration in ALS

Professor Eran Perlson, Tel Aviv University.

Zoom (link will be given in Abstract).

Thursday 11 November 2021, 12:00-13:00

Passive brain tumour visualisation during surgery using computer vision

Dr Gita Khalili Moghaddam, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 04 November 2021, 12:00-13:00

"Altered synaptic ingestion by human microglia in Alzheimer's disease"

Dr Makis Tzioras, Centre for Discovery Brain Sciences, University of Edinburgh.

Zoom (link will be given in Abstract).

Thursday 14 October 2021, 12:00-13:00

“Biology in balance: human diploid genome integrity, gene dosage & genomic medicine”

Dr James Lupski, Baylor-Hopkins Center for Mendelian Genomics, Houston, US.

Zoom (link will be given in Abstract).

Thursday 07 October 2021, 16:00-17:00

“Facing the impact of dementia globally with a focus on translational studies to reduce risk”

Professor James Vickers, University of Tasmania.

Zoom (link will be given in Abstract).

Thursday 30 September 2021, 09:00-10:00

“B cell diversity in neuroinflammation”

Dr Anne-Katrin Proebstel, University of Basel.

Zoom (link will be given in Abstract).

Thursday 22 July 2021, 12:00-13:00

"Pathogenesis and Prevention of Retinal Detachment"

Martin Snead, Consultant Ophthalmic and Vitreoretinal Surgeon, Cambridge University Hospitals NHS Foundation Trust.

Zoom (link will be given in Abstract).

Thursday 15 July 2021, 12:00-13:00

“Glucose, Diabetes and the Brain"

Dr Mark Evans, Institute of Metabolic Medicine and Department of Medicine, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 08 July 2021, 12:00-13:00

“Truncated tau as a model of human tauopathy”

Professor Diane Hanger, King's College London.

Zoom (link will be given in Abstract).

Thursday 24 June 2021, 12:00-13:00

Molecular traits of cell type-specific reactivity in neuroinflammation

Dr Lucas Schirmer, Manheim Center for Translational Neuroscience, Heidelberg University.

Zoom (link will be given in Abstract).

Thursday 27 May 2021, 12:00-13:00

Genomically Humanised Mouse Models For ALS Research

Dr Thomas Cunningham, MRC Harwell Institute.

Zoom (link will be given in Abstract).

Thursday 20 May 2021, 12:00-13:00

From mechanisms to treatment, in disorders of frontotemporal lobar degeneration

Professor James Rowe, Department of Clinical Neurosciences, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 06 May 2021, 12:00-13:00

The suprachiasmatic body clock: circadian genes, cells and circuits

Dr Michael Hastings, Division of Neurobiology, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 29 April 2021, 12:00-13:00

“Chemical genetic approaches for elucidating PARP function in cells”

Dr Michael Cohen, Department of Chemical Physiology and Biochemistry, Oregon Health and Science University.

Zoom (link will be given in Abstract).

Thursday 22 April 2021, 17:00-18:00

Immune/inflammatory mechanisms in stroke

Professor Stuart Allan, University of Manchester.

Zoom (link will be given in Abstract).

Thursday 18 March 2021, 12:00-13:00

Mechanisms of distal axon degeneration and neuroprotection in peripheral neuropathies

Ahmet Hoke, Professor of Neurology & Neuroscience, Johns Hopkins University School of Medicine.

Zoom (link will be given in Abstract).

Thursday 04 March 2021, 14:00-15:00

Imaging the locus coeruleus in Parkinsonian disorders

Dr Luca Passamonti, Dept of Clinical Neurosciences, University of Cambridge.

Zoom (link will be given in Abstract).

Thursday 25 February 2021, 12:00-13:00

Perineuronal net (PNN): an exoskeleton for neurons

Dr Jessica Kwok, School of Biomedical Sciences, University of Leeds.

Zoom (link will be given in Abstract).

Thursday 18 February 2021, 12:00-13:00

Directed Evolution of Adeno-associated Viral Variants Optimized for Clinical Gene Therapy

Professor David Schaffer, University of California at Berkeley.

Zoom (link given in Abstract).

Thursday 11 February 2021, 17:00-18:00

Directed Evolution of Adeno-associated Viral Variants Optimized for Clinical Gene Therapy

Professor David Schaffer, University of California at Berkeley.

Zoom (link given in Abstract).

Thursday 11 February 2021, 17:00-18:00

Human pain channelopathies

Professor David Bennett, Nuffield Dept of Clinical Neurosciences, University of Oxford.

Zoom (link will be given in Abstract).

Thursday 28 January 2021, 12:00-13:00

“Autoantibodies, receptors and ion channels in stiff person syndromes”

Dr Sarah Crisp, NIHR Clinical Lecturer in Clinical Neurosciences, University of Cambridge.

Zoom (link given in Abstract).

Thursday 21 January 2021, 12:00-13:00

fMRI across the lifespan: is it good enough to be BOLD?

Dr Kamen Tsvetanov, Centre for Speech, Language and the Brain, University of Cambridge.

Zoom (link given in Abstract).

Thursday 14 January 2021, 12:00-13:00

The impact of systemic inflammation on the vulnerable brain: at the interface of dementia and delirium

Dr Colm Cunningham, Trinity College Dublin.

Zoom (link given in Abstract).

Thursday 07 January 2021, 12:00-13:00

Physiological, humanised mouse models for neurodegenerative disease

Professor Elizabeth Fisher, UCL Queen Square Institute of Neurology.

Zoom (link given in Abstract).

Thursday 10 December 2020, 12:00-13:00

Chromatin remodelling determines cell-type specific Notch activity in the developing mouse brain

Dr Jelle van den Ameele, MRC Mitochondrial Biology Unit, University of Cambridge.

Zoom (link given in Abstract).

Thursday 03 December 2020, 12:00-13:00

Genetic modifiers in Huntington’s disease: an expanding tale

Professor Lesley Jones, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University.

Join Zoom Meeting https://us02web.zoom.us/j/89780335708?pwd=NFpVSk15bWJWTU5pcjNrOGtQckNidz09 Meeting ID: 897 8033 5708 Passcode: 171881.

Thursday 26 November 2020, 12:00-13:00

Starting a research project at the Clinical School - Ethics and other considerations

Carolyn Read - Research Governance Officer, School of Clinical Medicine, University of Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 25 July 2019, 12:00-13:00

Crossing over OMICS in mitochondrial diseases affecting the optic nerve

Guy Lenaers, University of Angers - France.

IPH large seminar room.

Thursday 06 June 2019, 12:00-13:00

The Ultrastructure of Retinal Circuitry in Health and Disease

Bryan Jones - University of Utah.

James Fawcett Seminar Room, van Geest Building.

Thursday 23 May 2019, 12:00-13:00

Microglia-mediated synapse loss in neurodegeneration: novel roles for TDP-43

Rosa Chiara Paolicelli, University of Lausanne.

James Fawcett Seminar Room, van Geest Building.

Thursday 16 May 2019, 12:00-13:00

To initiate and share opportunities for people to participate in activities linked to research on Parkinson’s disease

East of England Research Interest Group - Parkinson's UK.

James Fawcett Seminar Room, van Geest Building.

Thursday 02 May 2019, 12:00-13:00

Phenomapping mtDNA. New perspectives in personalised medicine

Aurora Gomez-Duran, University of Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 11 April 2019, 12:00-13:00

Direct neuronal reprogramming of patient skin fibroblasts: a new approach to study idiopathic Parkinson's disease

Janelle Drouin-Ouellet, University of Montreal.

James Fawcett Seminar Room, van Geest Building.

Thursday 04 April 2019, 12:00-13:00

Calcium-mediated processes as a potential common denominator in motor neuron degeneration

Roland Patai, Hungarian Academy of Sciences.

James Fawcett Seminar Room, van Geest Building.

Thursday 28 March 2019, 12:00-13:00

The new framework in European Family Law

Lucia Ruggieri, University of Camerino.

Herchel Smith Building.

Monday 25 March 2019, 17:00-19:00

Neurons without batteries: Dissecting cell type-specific neuronal contribution to mitochondrial disease

Albert Quintana, Universitat Autònoma de Barcelona.

James Fawcett Seminar Room, van Geest Building.

Thursday 07 March 2019, 12:00-13:00

Long-term stability of human neurons in an organotypic slice culture system – a new model to study disease mechanisms of neurological disorders

Henner Koch, University of Tübingen.

James Fawcett Seminar Room, van Geest Building.

Thursday 28 February 2019, 12:00-13:00

Influencing axon regeneration after spinal cord injury

Mark A. Anderson - Swiss Federal Institute of Technology, Lausanne and the University of California, Los Angeles.

IPH large seminar room.

Thursday 14 February 2019, 12:00-13:00

Exploring disease mechanisms in a novel group of neurological diseases caused by mutations in the RNA exosome

Juliane Muller, University of Cambridge (previously Newcastle University).

James Fawcett Seminar Room, van Geest Building.

Thursday 07 February 2019, 12:00-13:00

Gene therapy for glaucoma

Keith Martin, University of Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 10 January 2019, 12:00-13:00

Using Drosophila models to decipher rare and common neurological disorders

Zhai, Grace R. University of Miami.

James Fawcett Seminar Room, van Geest Building.

Friday 14 December 2018, 13:00-14:00

The coding and non-coding transcriptome of the human fetal striatum from a single-cell perspective

Vittoria Bocchi - University of Milan.

James Fawcett Seminar Room, van Geest Building.

Thursday 13 December 2018, 12:00-13:00

Whole-Tissue 3D Imaging to Decipher the Neuro-Immune Interplay in Physiology and Disease

Jing Yang, Peking University.

James Fawcett Seminar Room, van Geest Building.

Tuesday 11 December 2018, 11:00-12:00

Graded levels of Schwann cell c-Jun in vivo determines effects on development, remyelination and tumorigenesis

Shaline Fazal, University of Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 29 November 2018, 12:00-13:00

Investigating mechanisms of synaptic dysfunction in an organotypic slice culture model of Alzheimer's disease

Claire Durrant (née Harwell), University of Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 15 November 2018, 12:00-13:00

Chronic traumatic encephalopathy. A vascular problem?

Steve Gentleman - Imperial College London.

James Fawcett Seminar Room, van Geest Building.

Wednesday 31 October 2018, 12:00-13:00

Engineered neural networks as self-organised computational substrates in the healthy and lesioned CNS

Ioanna Sandvig - Norwegian University of Science and Technology.

James Fawcett Seminar Room, van Geest Building.

Thursday 25 October 2018, 12:00-13:00

Redefining microglia states in health and disease

Hammond Timothy - Boston Children's Hospital, Harvard Medical School.

James Fawcett Seminar Room, van Geest Building.

Thursday 11 October 2018, 12:00-13:00

Boosting functional recovery in the optic nerve

Jonathan Crowston, University of Melbourne.

James Fawcett Seminar Room, van Geest Building.

Tuesday 02 October 2018, 12:00-13:00

Neuronal Intrinsic and Extrinsic Factors Modulating Axon Growth After Spinal Cord Injury in Young and Aged Mice

Cédric G Geoffroy - Texas A&M University.

James Fawcett Seminar Room, van Geest Building.

Tuesday 11 September 2018, 11:45-12:45

Neuron-glia signalling mechanisms regulating brain development, homeostasis and pathological cascades

HARDINGHAM Giles - University of Edinburgh.

James Fawcett Seminar Room, van Geest Building.

Thursday 06 September 2018, 12:00-13:00

How do mitochondrial DNA mutations arise and cause neurological disease?

Professor Patrick Chinnery, Dep Clinical Neurosciences, Cambridge.

James Fawcett Seminar Room, van Geest Building.

Thursday 26 July 2018, 12:00-13:00

"to be confirmed"

Shamma Qarin, Dep Clinical Neurosciences, Cambridge.

James Fawcett Seminar Room, van Geest Building.

Friday 13 July 2018, 12:00-13:00

"Mitochondrial Dynamics and Diversity in the Nervous System"

Thomas Misgeld, Chair of the Institute of Neuronal Cell Biology, Technical University of Munich.

James Fawcett Seminar Room, van Geest Building.

Thursday 12 July 2018, 12:00-13:00

"EEG correlates of entorhinal cortex dysfunction in MCI" & "TBC"

Zoe Adler and David Nesbitt, Dep Clinical Neurosciences, Cambridge.

James Fawcett Seminar Room, van Geest Building.

Friday 06 July 2018, 12:00-13:00

"Highlighting the benefit of a dual vector construct " & "Fractal Dimension as a Measure of Complexity & Consciousness"

Terance Mensah & Thomas Varley, Dep of Clinical Neurosciences, Cambridge.

James Fawcett Seminar Room, van Geest Building.

Friday 29 June 2018, 12:00-13:00

"Activity-dependence of myelination" and "Relating Entropy and Integration in Anaesthesia and Disorders of Consciousness"

Jennifer Jia and Andrea Luppi, Dep Clinical Neuroscience, Cambridge.

James Fawcett Seminar Room, van Geest Building.

Tuesday 19 June 2018, 12:00-13:00