University of Cambridge > Talks.cam > BPI Seminar Series > Bob Groves - I'm Glovin' It and Alex Routh - How do LEA proteins operate?

Bob Groves - I'm Glovin' It and Alex Routh - How do LEA proteins operate?

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Bob Groves – I’m Glovin’ It Aqueous polymer dispersions are versatile materials used in the production of many familiar items, including paints, tyres, adhesive and carpets. Another member of this family is the humble rubber glove, made in billions per year.

In this talk, the nature and production of synthetic polymer dispersions is explained. Reasons are suggested why one such dispersion, known as nitrile latex, has become widely used to make rubber gloves, including the ubiquitous purple glove. Glove manufacture is discussed and some recent advances in understanding its details are presented. Current work in BPI , aimed at reducing the environmental impact of glove production, is described.

Alex Routh – How do LEA Proteins Operate? Some organisms can survive freezing and thawing. One example is a nematode and how they survive is not known. It is hypothesised that the nematodes exude intrinsically disordered proteins and these protect globular proteins from denaturating during freezing. We grow nematode intrinsically disordered proteins in e-coli and show that it does indeed protect a model globular protein (pig heart citrate synthase) through many rounds of freeze-thaw. Using multiple techniques we find no interaction between the two proteins.

We deuterated the intrinsically disordered protein and using neutron reflectivity we show how the IDP preferentially adsorbs at the air-water interface. This stops the citrate synthase from unfolding at the hydrophobic interface.

This talk is part of the BPI Seminar Series series.

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