The Mechanics of DNA and its Assemblies: From Twist-Bend Coupling to Cholesteric Liquid Crystals

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• Professor Jonathan Doye, University of Oxford
• Wednesday 03 October 2018, 14:15-15:15
• Department of Chemistry, Cambridge, Unilever lecture theatre.

If you have a question about this talk, please contact Lisa Masters.

In this talk, I will provide an overview of the insights that have been obtained into the mechanical properties of DNA and its assemblies using oxDNA, a coarse-grained nucleotide-level DNA model developed in the Doye and Louis groups. Topics will include twist-bend coupling, DNA overstretching, extreme bending, polymerase binding, plectoneme formation (including in the presence of DNA damage), solenoid formation, the properties of extremely underwound (L-DNA) and overwound (P-DNA), the elastic properties of DNA origamis, the unravelling of DNA origamis under tension, and the cholesteric liquid-crystalline properties of both duplex DNA and twisted rod-like DNA origamis.

This talk is part of the Theory - Chemistry Research Interest Group series.

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