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Molecular Studies in Vascular Dementia

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If you have a question about this talk, please contact Gabriella Heller.

Damage in brain blood vessels contributes to cognitive impairment in most cases of Alzheimer’s disease. Vascular dementia is the second most common dementia subtype after Alzheimer’s. Unlike Alzheimer’s disease where culprit molecules are well established, notably APP -derived beta-amyloid and hyper-phosphorylated tau protein, brain vascular disease lacks molecular targets and urgently needs better chemistry.

Atticus Hainsworth’s group test molecular hypotheses in human brain tissue and in experimental models. We are especially interested in brain endothelial cells, blood-brain barrier dysfunction and white matter lesions. We recently completed a phase II clinical trial, testing the phosphodiesterase inhibitor drug tadalafil for possible repurposing in vascular dementia.

This talk is part of the Biophysical Seminars series.

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