From dyfunction of the PINK1/Parkin pathway to Parkinson’s disease

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• Dr Olga Corti | ICM, Paris
• Wednesday 06 February 2019, 15:00-16:00
• Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building, Cambridge Biomedical Campus.

If you have a question about this talk, please contact Hannah Burns.

Mitochondrial dysfunction has long been suspected to play a role in the pathogenesis of Parkinson’s disease. This hypothesis has received strong support in recent years, with the discovery of gene responsible for familial Parkinson’s disease playing roles in mitochondrial maintenance. The products of the PINK1 and PARK2 (Parkin) genes cooperate in sensing mitochondrial dysfunction and linking it to the activation of protective mitochondrial quality control programs, including mitophagy. Despite the remarkable advances in our understanding of the molecular mechanisms by which PINK1 and Parkin promote mitophagy, little is known about how their dysfunction leads to neuronal degeneration. I will present recent efforts from our laboratory to characterize mechanisms by which PINK1 and Parkin preserve the quality of mitochondria and understand how dysfunction of this multifunctional pathway leads to neuronal degeneration in Parkinson’s disease.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC Mitochondrial Biology Unit Seminars
• Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building, Cambridge Biomedical Campus
• Trust & Technology Initiative - interesting events

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