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Investigating the propagation and spreading of protein aggregates in C. elegans

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Many neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease are associated with the gradual accumulation and characteristic spreading of pathological proteins. Mechanisms underlying the prion-like propagation of protein aggregates remain, however, largely elusive. I will present our ongoing work using the nematode Caenorhabditis elegans as a model system to discover and examine cellular pathways and factors that influence the propagation and intercellular spreading of disease-associated proteins (e.g., α-Synuclein) in metazoans. A better understanding of these mechanisms might eventually identify new druggable targets for the treatment of neurodegenerative diseases.

This talk is part of the Biophysical Seminars series.

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