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Melville Lectures "Breakable and self-assembled materials: Synthesis and applications"

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Despite the substantial progress that has been made in biomaterials synthesis and functionalization, the challenge of delivery in vivo in desired organs biomolecules or drugs and to mimic the ECM with implants that are able to reduce immunoresponse is still unmet. Towards this aim, we reported a novel biocompatible hydrogel with the ability to release a migration-inducing factor, for the recruitment of stem cells. The hydrogel is a composite made of breakable container –type materials able to respond to an external stimulus [1]. In particular we devoted much effort in the creation of “containers’ able to break in small fragments (

[1] F. Fiorini, et al. Small, 2016, 12, 4881 [2] L. Maggini, et al. Nanoscale, 2016, 8, 7240 [3] L. Maggini, et al. Chem. Eu. J., 2016, 22, 3697 [4] L. Travaglini, et al. Mater. Chem. Front., 2019, 3, 111 [5] E.A. Prasetyanto, et al. Angew. Chem. Int. Ed. 2016, 55, 3323. [6] G. Alonci et al. ACS Appl. Bio Mater., 2018, 1, 1301.

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