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The parallelism of evolution of multi-drug resistant clones

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Escherichia coli is an extremely diverse bacterial species composed of thousands of distinct lineages. Despite many of these lineages (presumably) inhabiting identical niches, and therefore undergoing identical selection pressures, only a handful of lineages have emerged as dominant, globally disseminated MDR clones. Large scale genomic analysis of these MDR clones, and contextual comparison against the background population from which they emerge, has allowed us to identify a number of key evolutionary steps in the emergence of these MDR clones, and their parallelism across a number of the most globally dominant MDR clones. Combining genomics with experimental evolution and classical molecular microbiology is allowing us to confirm these key mechanisms that underpin the evolution of successful MDR clones of E. coli

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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