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Reverse engineering cell mechanics

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If you have a question about this talk, please contact Jurij Kotar.

Cells are highly coordinated machines that depend on mechanics for a wide range of behaviors. Cell movements and shape change are essential for tissue development and repair, while changes in the mechanical and motile properties of cells are associated with a growing number of diseases including cancer. In this talk, I will present our recent efforts to understand the cytoskeletal structures that govern the mechanical properties and movements of cells. We use a combination of force microscopy, optical microscopy, and microfluidics to investigate actin filament networks in both whole cells and purified protein reconstitutions. The ability to control assembly of cytoskeletal structures may enable new understanding of disease mechanisms and could offer the ability to engineer new cell-like systems for health applications.

This talk is part of the BSS Formal Seminars series.

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