COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |

University of Cambridge > Talks.cam > CUED Control Group Seminars > Limits of precision in stochastic cell biology

## Limits of precision in stochastic cell biologyAdd to your list(s) Download to your calendar using vCal - Glenn Vinnicombe, University of Cambridge
- Thursday 23 May 2019, 14:00-15:00
- Cambridge University Engineering Department, Lecture Theatre 6.
If you have a question about this talk, please contact Alberto Padoan. We look at two related problems where noise and small numbers provide limitations on the behaviour of cells. Firstly “The Poisson box”: For a simple birth death process (constant birth rate, exponential deaths) it is well known that the variance equals the mean. We conjecture that for two coupled birth death processes it is not possible for both processes to simultaneously beat this bound. That is, if X is controlling Y, and vice versa, then in order for the variance in Y to be reduced below the Poisson limit then the variance in X must be above it. For cell biology, this suggests that large fluctuations in the population of one molecular species might be a natural consequence of it being implicated in regulating a second. The conjecture is known to hold in some circumstances – a general proof remains elusive though. Secondly, Optimal clocks: How do you make accurate clocks from small numbers of independent random events (such as the production, degradation or modification of a molecule). If the number of events/molecules is fixed then the answer is well known – you line up the events, one after the other, all with the same rate. If the number of events is itself random then the optimal topology can be much more complex. However, for many distributions the optimal answer is well approximated by a simple mechanism, one which we have implemented as part of a synthetic oscillator in E-coli. This talk is part of the CUED Control Group Seminars series. ## This talk is included in these lists:- All Talks (aka the CURE list)
- CUED Control Group Seminars
- Cambridge Centre for Data-Driven Discovery (C2D3)
- Cambridge University Engineering Department Talks
- Cambridge University Engineering Department, Lecture Theatre 6
- Centre for Smart Infrastructure & Construction
- Chris Davis' list
- Featured lists
- Information Engineering Division seminar list
- Interested Talks
- School of Technology
- Signal Processing and Communications Lab Seminars
- Trust & Technology Initiative - interesting events
- bld31
- ndk22's list
- rp587
Note that ex-directory lists are not shown. |
## Other listsKarma Talkies Biological Bioenergy Initiative## Other talksStochastic Sylvester equations for output regulation of linear stochastic systems Statistics Clinic Easter 2019 - IV Determination of protein structure and dynamics with integrative approaches Real-Time Monitoring to Inform the Construction of Large-Diameter Caissons Materials Chemistry to Mimic Living Matter Balancing the Grid through Distributed Control of Flexible Loads |