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In vitro and in vivo computational models of heart valve dynamics

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FHTW01 - Uncertainty quantification for cardiac models

Heart valves are thin elastic structures that move with the blood flow, but at the same time, they apply forces to the flow that alter the fluid motion. Simulating heart valve performance across the full cardiac cycle requires a fluid-structure interaction approach. This talk will describe work to develop and to validate fluid-structure interaction (FSI) models of native and bioprosthetic heart valves. We consider models of in vitro systems that can provide detailed experimental data in a controlled, reproducible environment as well as subject-specific models of the heart. Initial validation results show excellent agreement between simulated and experimental flow, pressure, and valve kinematics data acquired from the experimental system. We also will present recent work that is developing a complete fluid-structure interaction model of the heart that includes anatomically and biomechanically realistic descriptions of the atria, ventricles, the four cardiac valves, and the nearby great vessels.

This talk is part of the Isaac Newton Institute Seminar Series series.

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