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University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Efficient Quantification of Left Ventricular Function During the Full Cardiac Cycle Using a Characteristic Deformation Model

## Efficient Quantification of Left Ventricular Function During the Full Cardiac Cycle Using a Characteristic Deformation ModelAdd to your list(s) Download to your calendar using vCal - Brian Hong (None / Other)
- Thursday 06 June 2019, 12:00-12:30
- Seminar Room 1, Newton Institute.
If you have a question about this talk, please contact info@newton.ac.uk. FHTW01 - Uncertainty quantification for cardiac models Heart failure is a significant source of morbidity and the prevalence of heart failure continues to rise. Quantification of cardiac function beyond standard clinical indices is essential to improving heart failure diagnosis specificity. Patient-specific computational models of the heart offer detailed descriptions of cardiac function suitable for this purpose. Such models are typically constructed using 0D “varying elastance” or 3D Finite element method (FEM) approaches. While both methods have been successfully applied to many patient-specific applications, each has limitations. Varying elastance models are limited by their simplified representation of the myocardium while FEM models have a high computational cost that is restrictive in applications that require the simulation of many cardiac cycles. As an alternative to these approaches, we describe a computationally efficient method for simulating the dynamics of the left ventricle (LV) in three dimensions using characteristic deformation modes (CDM). In the CDM -LV model, LV motion is represented as a combination of a limited number of deformation modes, chosen to represent observed cardiac motions. A variational approach is used to incorporate a mechanical model of the myocardium. Passive stress is governed by a transversely isotropic elastic model. Active stress acts in the fiber direction and incorporates length-tension and force-velocity properties of cardiac muscle. This talk is part of the Isaac Newton Institute Seminar Series series. ## This talk is included in these lists:- All CMS events
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