A singular view of DNA transactions

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• Dr Gijs Wuite, Department of Physics and Astronomy, VU University Amsterdam, Netherlands
• Friday 28 November 2008, 14:15-15:15
• Small Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Jurij Kotar.

The genetic information of an organism is encoded in the base pair sequence of its DNA . Many specialized proteins are involved in organizing, preserving and processing the vast amounts of information on the DNA . In order to do this swiftly and correctly these proteins have to move quickly and accurately along and/or around the DNA constantly rearranging it. In order to elucidate these processes we perform single-molecule experiments on model systems such as restriction enzymes, bacterial gene regulators and repair proteins.

The data we use to extract forces, energies and mechanochemistry driving these dynamic transactions. The results obtained from these model systems are then generalized and thought to be applicable to many DNA -protein interactions.

This talk is part of the BSS Formal Seminars series.

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