Arterial redox signalling in the control of bood pressure under inflammatory conditions

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• Professor Roland Stocker | Victor Chang Cardiac Research Institute, Australia
• Thursday 13 February 2020, 15:30-16:30
• Sackler Lecture Theatre (Level 7) The Keith Peters Building, Cambridge Biomedical Campus.

If you have a question about this talk, please contact Hannah Burns.

Under inflammatory conditions, the haem-containing indoleamine 2,3-dioxygenase 1 is expressed in arterial endothelial cells. In the presence of hydrogen peroxide, the endothelial enzyme generates 1O2 and that this is associated with the stereoselective oxidation of L-tryptophan to a tricyclic hydroperoxide via a previously unrecognized oxidative activation of the dioxygenase activity. The tryptophan-derived hydroperoxide acts in vivo as a signalling molecule, inducing arterial relaxation and decreasing blood pressure; this activity is dependent on Cys42 of protein kinase G1α. Our findings demonstrate a pathophysiological role for singlet oxygen in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure under inflammatory conditions.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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• MRC Mitochondrial Biology Unit Seminars
• Sackler Lecture Theatre (Level 7) The Keith Peters Building, Cambridge Biomedical Campus
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