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Discovering the gene networks that regulate hunger

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Studying a rare disease with extreme clinical features can lead to new treatments for patients, and can also uncover underlying mechanisms relevant to common disorders and population health. The Genetics of Obesity Study (GOOS, http://www.goos.org.uk ) recruited thousands of individuals with severe early-onset childhood obesity and led to the identification of rare genetic variants affecting key processes in the hypothalamus, a part of the brain involved in appetite, weight regulation and energy balance. To gain further insights our current work encompasses the genetics of rare severe childhood obesity and the genetics of thinness. We combine large genomic data sets from different populations and platforms with detailed clinical information to discover new pathways involved in appetite, weight regulation and associated disorders.

This talk is part of the Computational and Systems Biology series.

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