University of Cambridge > Talks.cam > Genetics Seminar  > Bacterial condensates under stress

Bacterial condensates under stress

Add to your list(s) Download to your calendar using vCal

  • UserProfessor Stephanie Weber, McGill University, Montreal
  • ClockThursday 21 October 2021, 14:00-15:00
  • HouseZoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Host: Rosana Collepardo

Living cells are divided into functional compartments called organelles. In eukaryotes, lipid membranes separate organelles from the cytoplasm such that each compartment maintains a distinct biochemical composition that is tailored to its function. In contrast, prokaryotes typically lack internal membranes and instead must use other mechanisms to spatially organize the cell. Using fluorescence imaging and single-molecule tracking, we show that E. coli RNA polymerase (RNAP) organizes into clusters through liquid-liquid phase separation (LLPS). RNAP clusters, or “condensates”, increase cell survival during stress, and appear to regulate ribosome biogenesis in response to nutrient availability. Our results demonstrate that bacteria, like eukaryotic cells, use LLPS to generate membraneless organelles that spatially organize biochemical processes to optimize cell fitness in various environments.

This talk is part of the Genetics Seminar series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2021 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity