Epigenetics and genome dynamics: what can we learn from ciliates?

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• Dr Sandra Duharcourt, Institut Jacques Monod, Universite de Paris
• Thursday 20 October 2022, 14:00-15:00
• Zoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Host - Eric Miska

The epigenetic landscape is established and maintained by different protein complexes in transcriptionally active versus silent regions of the genome. Polycomb Repressive Complex (PRC2) deposits the histone mark H3K27me3 on silent protein-coding genes, while transposable elements are repressed by DNA and/or H3K9 methylation. Yet, there is increasing evidence that PRC2 also targets and even silences transposable elements (TEs) in representatives of several distantly related eukaryotic lineages, including the ciliate Paramecium. What determines the specificity of recruitment for PRC2 to the TEs that it represses is unknown. Our recent work shows that Paramecium PRC2 undergoes a direct physical interaction with the RNA interference machinery and we precisely delineate the mechanistic basis of PRC2 recruitment to TEs and its molecular participants. Our findings not only shed light on small RNA -guided PRC2 targeting to TEs, but also reveal parallels with TE recruitment pathways for other classes of repressive histone methyltransferases and therefore provide a new evolutionary context for understanding TE silencing more broadly.

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