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Mitochondria: portrait of an inflammatory killer

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Mitochondria play an essential role in apoptotic cell death. The textbook view of apoptosis is as a silent form of cell death; this makes intuitive sense given the billions of cells that die each day through apoptosis. Nonetheless, recent work from us and others has shown that alongside triggering cell death, mitochondria elicit inflammation. Some of these inflammatory pathways likely stem from the bacterial ancestry of mitochondria. I will discuss how mitochondria can engage cell-death associated inflammation and how we can therapeutically harness these processes to improve cancer treatment. Finally, I will discuss our recent efforts to understand “day jobs” of cell-death associated inflammation, specifically in the context of senescence and aging.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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