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Diversity of brain macrophages

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The central nervous system (CNS) hosts a variety of tissue macrophages, including parenchymal microglia, as well as border-associated macrophages such as meningeal and perivascular macrophages. Recent studies using transgenic animals, transcriptomic and proteomic technologies have enhanced our understanding of the ontogeny and diversity of CNS macrophages. In this presentation, I will show that microglia and meningeal macrophages share a common prenatal progenitor, whereas perivascular macrophages originate only after birth in an integrin-dependent manner. The establishment of perivascular macrophages requires the presence of arterial vascular smooth muscle cells.

This talk is part of the Microglia webinar series series.

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