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RNA cap regulation in cell function and fate decisions

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  • UserProfessor Vicky Cowling; School of Life Sciences, University of Dundee World_link
  • ClockThursday 10 March 2022, 13:30-14:30
  • HouseOnline via zoom.

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Vicky Cowling is a group leader at the School of Life Sciences, University of Dundee. Her research team investigates how modification of RNA by the addition of methylated cap structures impacts on gene expression. The Cowling lab discovered that formation of the RNA cap is regulated by cellular signalling pathways, resulting in changes in RNA expression, processing and translation. RNA cap regulation typically co-regulates specific families of genes with related functions, thereby impacting on cell function and fate decisions. The current focus of the lab is on understanding how RNA cap formation is regulated during embryonic stem cell differentiation, neuron stimulation and T cell activation. The Cowling lab also works with the Dundee Drug Discovery Unit to develop RNA capping inhibitors with the aim of suppressing tumour cell growth and immune cell function. The lab is predominantly funded by the European Research Council (ERC) and Wellcome Trust.

Vicky carried out her PhD research at the Cancer Research UK London Research Institute, working with Julian Downward and Gerard Evan, investigating mechanisms of caspase activation during apoptosis. She carried out her postdoctoral research with Michael Cole at Princeton University and Dartmouth College, USA , investigating c-Myc oncogene function.

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