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Chemically modifying surfaces and biomolecules for nanopore analysis

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Nanopores analytics is an attractive electrical technique. In nanopore analytics, individual molecules pass through a nanopore and cause detectable changes in pore conductance. Chemistry can be applied to enhance nanopore analytics. Firstly, small chemical tags can be attached to analyte molecules to generate a unique current signature. This has been exemplary demonstrated by linking chemical tags to bases in DNA strands. The tags caused unique current blockades thereby enabling the detection of individual bases in translocating DNA strands. In addition, chemistry is expected to help tailor the properties of solid-state nanopores. Surface engineering has the potential, for example, to avoid the undesired non-specific interaction between analytes and the pores. In addition, chemistry is also capable of engineering defined analyte recognition sites into blank pores. Based on recent work on the chemical modification of planar substrates, examples are given on how coatings composed of hydrophilic polymers improve the properties of inorganic surfaces.

This talk is part of the BSS Formal Seminars series.

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