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Axon guidance and local RNA-based mechanisms of directional steering

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  • UserChristine Holt Department of Physiology, Development and Neuroscience, Anatomy Building, Downing Street, University of Cambridge, Cambridge CB2 3DY
  • ClockTuesday 31 March 2009, 14:10-14:55
  • HouseCripps Court, Magdalene College.

If you have a question about this talk, please contact Anna Di Pietro.

Synaptic connections between distant neurons are first established by axons navigating along specific pathways. A key aspect of this navigation is its remarkable accuracy and we are trying to understand the molecular and cellular basis of this precision-guided growth. Early pathways, while physically continuous, are sub-divided into molecularly distinct domains and growing axons are guided from one segment to the next by successive encounters with guidance cues. The motile tip of growing axons, the growth cone, contains mRNAs and translation machinery and guidance cues such as netrin and semaphorin elicit rapid protein synthesis in growth cones. This lecture will focus on an RNA -based mechanism of directional steering in Xenopus retinal axons with particular consideration of the role of spatially localised translation.

This talk is part of the Spring School 2009 - "Regeneration and Plasticity of Neural Circuits" series.

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