Lymphoid tales: TNFAIP8 in glucocorticoid killing – E4BP4 and the origin of NK cells

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• Dr Hugh Brady, Division of Immunology and Infection, Imperial College London
• Monday 12 October 2009, 12:30-13:30
• Lecture Theatre, Department of Pathology, Tennis Court Road.

If you have a question about this talk, please contact Prof. Jim Kaufman.

Host: Ashley Moffet (am485@cam.ac.uk)

Glucocorticoids have significant immunoregulatory actions on thymocytes and T-cells and promote cell death by activating an apoptotic programme that requires transcriptional regulation. Candidate genes to regulate glucocorticoid-mediated thymocyte apoptosis were identified by DNA microarray and and assayed in reconstituted fetal thymic organ culture (FTOC). Based on this we propose that Tnfaip8 is crucial gene in regulating glucocorticoid-mediated apoptosis of thymocytes.

Natural Killer (NK) cells are an integral part of innate immunity and also have significant influence on the regulation of adaptive immunity. We have identified E4bp4 as a gene responsible for specifying NK cell lineage commitment and shown that mice lacking E4bp4 have no NK cells. E4bp4 acts via the Id2 transcription factor to control NK cell production.

This talk is part of the Immunology in Pathology series.

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