University of Cambridge > Talks.cam > BSS Formal Seminars > Wires, Reporters and Information Capsules: Cellular journalism with DNA.

Wires, Reporters and Information Capsules: Cellular journalism with DNA.

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DNA has attractive physicochemical characteristics such as robust thermal and hydrolytic stability. It also has desirable structural characteristics stemming from predictable and specific recognition properties that give rise to a highly regular helical structure which behaves as a rigid rod on length scales up to ~50 nm. Since these rigid rods may be welded together by complementary base-pairing, DNA is now taking on a new aspect where it is finding use as a construction element for architecture on the nanoscale. This field is called structural DNA nanotechnology. I describe approaches adopted by my lab where we demonstrate promising new self-assembly strategies that include the use of unusual forms of DNA in structural DNA nanotechnology to make molecular-scale devices. I will then go on to show the application of these DNA -based molecular devices in biological systems.

References: 1.Ghodke, H. B.; Krishnan, R.; Vignesh, K.; Kumar, G.V.P.; Narayana, C.; Krishnan, Y. (2007) The I-tetraplex building block: Rational Design and Controlled Fabrication of robust 1D DNA Scaffolds via non-Watson Crick self assembly. Angew. Chem. Int. Ed., 46, 2646-2649. 2. Bhatia, D., Mehtab, S., Krishnan, R., Indi, S.S., Basu, A., Krishnan, Y. (2009) Icosahedral DNA nanocapsules via modular assembly. Angew. Chem. Int. Ed. accepted. 3. Modi, S.; Swetha, M. G.; Goswami, D.; Gupta, G. D.; Mayor, S.; Krishnan, Y.* (2009) A DNA Nanomachine maps spatiotemporal pH in living cells. Nature Nanotechnology, 4, 325-330.

This talk is part of the BSS Formal Seminars series.

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