Regulation of Alternative Splicing by Histone Modifications

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• Reini Luco, National Cancer Institute, National Institutes of Health, Bethesda
• Friday 02 April 2010, 14:00-15:00
• Cancer Research UK Cambridge Research Institute, Room 215.

If you have a question about this talk, please contact Katrien Van Look.

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.

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