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Deconvolving the epigenome

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DNA methylation is a widespread epigenetic modification that has been implicated in many processes of transcriptional regulation, development, and disease. DNAm can be assayed using a ChIP-seq-like approach called MeDIP, but doing so poses analytical challenges not found in ChIP-seq data. We discuss approaches for analysing MeDIP data, and several recent findings concerning the landscape and variability of the DNA methylation mark.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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