Small Molecules and Light as Tools for the Regulation of Biological Proceeses

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• Alex Deiters, North Carolina State University, USA
• Wednesday 29 September 2010, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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The Deiters Lab is developing novel chemical tools for the perturbation and investigation of biological processes, most importantly gene function. Genes are precisely orchestrated in a spatio-temporal fashion; moreover, the activity of multiple genes is often wired to each other, thus creating highly complex genetic networks. In order to investigate genes and gene networks, regulation with Nature’s level of spatial and temporal resolution must be attained. Two examples of chemical regulation of specific biological processes will be presented in this lecture: 1) The development of light-activated oligonucleotides and their application to the photochemical regulation of gene function in mammalian cells and aquatic embryos, and 2) the development of the first small molecule inhibitors of microRNA function and their application as potential anticancer and antiviral agents.

This talk is part of the MRC LMB Seminar Series series.

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