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Transcriptional Regulation of Cell State

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Discovering how transcriptional regulation establishes and maintains gene expression programs in mammalian cells is important for understanding the control of cell state, the process of development and the mechanisms involved in various diseases. Embryonic stem cells (ESCs) provide a powerful model system for studying transcriptional regulation in early development. I will describe the key features of transcriptional regulatory circuitry that have emerged from studies in ESCs, including the roles that specific transcription factors, cofactors and chromatin regulators play in the establishment and maintenance of pluripotency and self-renewal. Advances in our understanding of the regulation of cellular gene expression programs are providing new insights into the mechanisms that contribute to a variety of diseases and are influencing development of therapeutics for these diseases.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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