University of Cambridge > Talks.cam > Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer > Integrated Solutions in Cancer Genomics

Integrated Solutions in Cancer Genomics

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Genomic medicine involves the provision of medical care that uses the power of genomic knowledge and technologies to resolve complex problems. This means knowing any or all mutations in the genes of an individual or an individual’s cancer. . We will describe how genomic approaches are changing our understanding of cancer, as a model system. We describe two strategic approaches pertinent to breast cancer: estrogen receptor dynamics, and genomic rearrangements in breast cancer using a single cell line, the MCF -7 cell line as a starting point. Iterative investigations that start with genomic discovery in a cell line proceeding to validation by database interrogation and biological assessment allow for a scale of exploration that is both comprehensive and precise. Higher order analysis of such data can provide a holistic mechanistic explanation that can encompass the complex and sometimes contradictory input-output associations seen in experimental systems.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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