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The Chemical Biology of Large-Scale Transcriptome Analysis

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Our laboratory is blending new RNA chemistries, largely directed at the ribose 2’-hydroxyl group, with quantitative interpretation to create new kinds of chemical microscopes for highly accurate RNA structure analysis. We apply these technologies to important, and otherwise intractable, problems in biology. We have developed a working model for the architecture of an entire HIV -1 genome. This secondary structure model represents, in essence, a diverse set of hypotheses for how RNA structure governs viral replication. Recent functional studies supporting many of these structural hypotheses, plus new work focused on understanding RNA tertiary structure, will be emphasized.

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