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How cells defend their cytosol against bacterial invasion

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Host: Jim Kaufman, jfk31@cam.ac.uk

The extracellular immune system commands antibodies and other powerful effector mechanisms, which are thought to be responsible for the hidden lifestyle of intracellular bacteria. Despite the abundance of nutrients in the cytosol most intracellular bacteria live in vesicles, suggesting cytosolic immunity is equally potent and the vesicular life style the path of least resistance for intracellular bacteria.

I will discuss how cells detect bacteria invading their cytosol, how such bacteria are marked with a poly-ubiquitin coat, and how they are targeted for autophagy.

This talk is part of the Immunology in Pathology series.

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