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Macrophage paired receptors - structure, interactions and evolution

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If you have a question about this talk, please contact Sue Griffin.

Host: Jim Kaufman, jfk31@cam.ac.uk

Paired receptors are families of membrane proteins that have very similar extracellular regions but different intracellular regions and signalling potential.

This paradox has been investigated by determining the fine structure of the members of the SIRP paired receptors family and a ligand CD47 . These structures indicate the molecular basis for the fine specificity of SIRP alpha and also to the evolution of antigen receptors. The combination of genetic analysis and structural data suggests molecular mechanisms for how pathogens are driving the rapid evolution of paired receptors and how the environment may be modulating immune responses.

This talk is part of the Immunology in Pathology series.

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