University of Cambridge > Talks.cam > Microsoft Research Cambridge, public talks > Fuzzy thinking: single neuron variation in RNA state space

Fuzzy thinking: single neuron variation in RNA state space

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Microsoft Research Cambridge Talks Admins.

A neuron is one of the most complex cells in our body. In particular, its functional units are individual processes (dendrites and axons) with their complement of synapses rather than the whole cell. In the last four years, we have been working with Jim Eberwine (Penn Pharmacology) to investigate the RNA metabolism underlying a neuron’s developmental phenotype and its dendritic function. Using whole transcriptome manipulations, we have demonstrated that cellular phenotypes can be transdifferentiated into other stable types. In particular, we have found that the RNA states underlying cell types is much more variable than previously thought. An important aspect of neuronal function is posttranscriptional regulation of subcellular localization of RNA . Using computational analysis, we found a surprising contribution from a rapidly evolving retroviral element in mediating RNA localization. Using comparative analysis of the dendritic transcriptome, we show high rates of divergence in post-transcriptional subcellular localization between rats and mice. We propose that evolution of neuronal function involves not only neuroanatomy but modulation of individual synaptic responses.

This talk is part of the Microsoft Research Cambridge, public talks series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2019 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity