Self-assembled DNA-nanostructure tools for molecular biophysics

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• William Shih, Harvard Medical School
• Monday 25 July 2011, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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Our group previously solved a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures. Our solution was to build custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA . I will discuss applications of this technology for molecular biophysics: (1) weak-alignment media for NMR structure determination of membrane proteins such as UCP2 , a 30 kDa six-transmembrane helix mitochondrial proton transporter; (2) scaffolds for determining the number of SNARE complexes required for lipid-bilayer fusion; (3) artificial actin filaments built as chimeras between protein and DNA for dissecting the mechanism of movement by processive myosin bipedal walkers.

This talk is part of the MRC LMB Seminar Series series.

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