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Programmable Self-Assembled DNA-Based Autonomous Molecular Devices

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This talk overviews recent work in the field of DNA -based autonomous biomolecular devices. We particularly emphasize molecular assemblies and molecular devices that are (i) self-assembled: that is they assemble into DNA nanostructures in one stage without explicit external control, (ii) programmable: the tasks the molecular devices execute can be modified without an entire redesign and (ii) autonomous: they operate without external mediation (e.g. thermal-cycling). We describe recent experimental progress in DNA -based autonomous biomolecular devices that achieve: 2D patterning, computation, amplified sensing, and molecular nano-scale transport. These have taken the technology from a state of intriguing possibilities into demonstrated capabilities of quickly increasing scale, and we describe a number of very promising applications in the biomedical industry.

This talk is part of the Microsoft Research Cambridge, public talks series.

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