University of Cambridge > Talks.cam > Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer > Modeling non-familial colon cancer susceptibility in mice

Modeling non-familial colon cancer susceptibility in mice

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Kate Davenport.

Many mouse models of colorectal cancer (CRC) have been developed, but the vast majority model familial forms of cancer. We have been exploiting a chemical model of colon cancer, azoxymethane (AOM) exposure, to model non-familial CRC . An extensive multi-strain comparison of the response to AOM -mediated tumorigenesis suggested genetic contribution to cancer, mirroring non-familial CRC in humans. We observed significant differences in susceptibility and In the present study, an extensive inbred strain profile was carried out using 39 inbred strains. A series of F1 and F2 crosses, and backcrosses between resistant and susceptible inbred strains in response to AOM showed a wide variety of strain differences in response to AOM and detailed analysis of inheritance patterns suggests that resistance to tumor development across populations is inherited in a dominant fashion. The model also revealed substantial genetic contribution to cancer morphology. Current studies are underway to identify biomarkers of susceptibility that can be used to identify the likelihood that an individual will develop cancer.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity