University of Cambridge > Talks.cam > Immunology in Pathology > Origin and Transformation of T Cell Progenitors

Origin and Transformation of T Cell Progenitors

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Sue Griffin.

Host: Jim Kaufman, jfk31@cam.ac.uk

We mapped the origin of the majority of T cell progenitors in the thymus to an interleukin 7 receptor (Il7r)-expressing progenitor, consistent with a lymphoid-primed route from bone marrow to thymus. Most of these T cell progenitors lacked myeloid potential in vivo, which argues against the recent notion that T cells and myeloid cells in the thymus share a common progenitor.

By contrast, using a T cell-biased Cre-deleter, we found that Notch1-deficient T cell progenitors were blocked in their T cell development, and gave rise to B cells as well as conventional and plasmacytoid dendritic cells in the thymus. A hallmark of T cell progenitors is their lack of self-renewal.

Hence, thymus function is thought to absolutely depend on continuous supply of new progenitors from the bone marrow. We uncovered the ability of the thymus for autonomous, i.e. bone marrow-independent T cell development. Normally, fit progenitors from the bone marrow prevail over exhausted progenitors in the thymus. Progenitor deprivation resulted in persistence of thymocytes, which frequently results in T cell acute lymphoblastic leukemia (T-ALL) arising in the thymus. These T-ALL share cellular and molecular hallmarks of human T-ALL.

These findings suggest that perturbed progenitor turnover can cause genomic instability and cancer.

This talk is part of the Immunology in Pathology series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2019 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity