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Multi-scale studies on Drosophila transcription factors

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Abstract: Transcription factors play a crucial role in the coordination of developmental gene expression programs. Our research concerns combinatorial aspects of transcription factor utilization in Drosophila, looking at both the level of organismic co-expression as well as co-binding to cis-regulatory modules. In this talk, I am going to focus on two seemingly unrelated observations, one concerning the constant reshuffling of transcription factors to form new co-expression clusters during embryonic development, the other concerning the highly similar binding patterns of different transcription factors in different tissues. I am going to present evidence that comparing apples with pears (or diverse genome-wide binding profiles) sometimes does make sense in genome-scale computational analyses, and conclude with a hypothesis why that is on the basis of the aforementioned seemingly unrelated observations.

This talk is part of the Computational and Systems Biology series.

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