University of Cambridge > > Brain Mapping Unit Networks Meeting and the Cambridge Connectome Consortium > Mapping overlapping, dynamic brain networks from resting-state FMRI

Mapping overlapping, dynamic brain networks from resting-state FMRI

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  • UserProfessor Stephen Smith, Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford
  • ClockTuesday 03 July 2012, 11:00-12:00
  • HouseMRC CBU, Chaucer Road.

If you have a question about this talk, please contact Mikail Rubinov.

Resting-state functional magnetic resonance imaging has become a powerful tool for the study of functional networks in the brain. Even “at rest,” the brain’s different functional networks spontaneously fluctuate in their activity level; each network’s spatial extent can therefore be mapped by finding temporal correlations between its different subregions. The talk will start with a brief background on the use of resting-state fluctuations to map functional networks, including our previous work showing correspondence between resting-state networks and networks found from explicit task-activation studies. I will then go on to describe our most recent work, where we reconsider how we should separate distinct networks from each other. Current correlation-based approaches measure the average functional connectivity between regions, but this average is less meaningful for regions that are part of multiple networks; one ideally wants a network model that explicitly allows overlap, for example, allowing a region’s activity pattern to reflect one network’s activity some of the time, and another network’s activity at other times. However, even those approaches that do allow overlap have often maximized mutual spatial independence, which may be suboptimal if distinct networks have significant overlap. In this work, we identify functionally distinct networks by virtue of their temporal independence, taking advantage of the additional temporal richness available via improvements in functional magnetic resonance imaging sampling rate. We identify multiple “temporal functional modes,” including several that subdivide the default-mode network (and the regions anticorrelated with it) into several functionally distinct, spatially overlapping, networks, each with its own pattern of correlations and anticorrelations. These functionally distinct modes of spontaneous brain activity are, in general, quite different from resting-state networks previously reported, and may have greater biological interpretability.

This talk is part of the Brain Mapping Unit Networks Meeting and the Cambridge Connectome Consortium series.

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