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“Genetic analysis of a somatically acquired trait: immunological self-tolerance ”

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Professor Chris Goodnow is Professor and Head of the Dept of Immunology at the Australian National University’s John Curtin School of Medical Research, and Founding Director and CSO of the Australian Phenomics Facility in Canberra. In May 2009 he was elected as a Fellow of the The Royal Society. Goodnow “has pioneered in the field of immunology to reveal key mechanisms regulating the immune system, in particular the ability of the immune system to learn to differentiate between our own “self” tissues and invading foreign microbes. He has also revealed the capacity of the immune system to lay down specific memory of both self and foreign, so that autoimmunity is minimised while immunity to infection becomes strong”. In this lecture he will present unpublished work analysing the acquisition of self-nonself discrimination by antibodies during germinal center reactions, and the impact of inherited and somatically acquired mutations in genes that are critical for B and T cell tolerance.

This talk is part of the Cambridge Biomedical Research Centre "Distinguished Visitors" 2015 Lecture Series series.

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