University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > Avian pathogenic E. coli (APEC): hidden genetic diversity in an economical important poultry pathogen

Avian pathogenic E. coli (APEC): hidden genetic diversity in an economical important poultry pathogen

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Avian pathogenic E. coli (APEC) are an important cause for losses in poultry industry, mainly affecting laying chickens. Although the pathogenesis of APEC has been investigated since two decades, neither transmission pathways nor key steps of pathogenicity are unravelled, and findings are contrasting each other. The talk will highlight recent findings from infection studies utilizing mutagenesis, and discusses these in the context of phylogenetic analyses of next-generation based whole genome sequencing. Our cumulative data reveal that APEC is a highly divers pathotype, that did not only develop on multiple occasions, but also by the uptake of different virulence-associated factors. Thus, the same avian disease is caused by different APEC via distinct mechanisms. These findings are highly important for a rational design of strategies to control a key animal disease.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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