University of Cambridge > Talks.cam > Departmental Seminar Programme, Department of Veterinary Medicine > Molecular mechanisms of synapse degeneration in prion and Alzheimer's disease

Molecular mechanisms of synapse degeneration in prion and Alzheimer's disease

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Synapse degeneration is the key event leading to memory failure in Alzheimer’s and prion diseases. Prions and amyloid-beta42 (thought to be the major neurotoxin in Alzheimer’s disease) trigger synapse damage in cultured neurons. In this talk I will discuss the molecular mechanisms of synapse damage in response amyloid-beta42 and prions including experimental data implicating the role of specific receptors, lipid rafts and signalling cascades. I will then discuss possible intervention strategies based on the manipulation of these molecular pathways.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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