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Foxp3, TSLP, and the regulation of immunity and inflammation

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Host: John Rogers, PDN (jhr11@cam.ac.uk)

The Ziegler lab is interested in factors that are involved in regulating immune responses in beneficial and pathogenic ways. We have identified the transcriptional regulator Foxp3 as a critical factor in the development and function of regulatory T cells, and have begun to define the pathways that control peripheral regulatory T cell generation. In addition, we are examining the role of medulary thymic epithelial cells in the development of regulatory T cells in the thymus.

In a separate set of studies we have found that the epithelial-derived cytokine TSLP (thymic stromal lymphopoietin) is an important initiator of atopic disease. Using both human and mouse systems we have identified the cells that respond to TSLP during allergic inflammatory responses, and have begun to investigate the pathways that are involved.

This talk is part of the Immunology in Pathology series.

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