Biological insights from cryo-EM studies of complex macromolecular assemblies in transcription initiation and microtubule dynamics

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• Eva Nogales, HHMI University of California Berkely
• Wednesday 24 July 2013, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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We are interested in the mechanistic understanding of essential eukaryotic molecular processes. Our research centers on cell division roles of the cytoskeleton, and on the making and breaking of macromolecules by molecular machines governing the flow of genetic information. We are visualizing these complex assemblies as whole units of molecular function using cryo-electron microscopy to characterize their architecture, functional states and regulatory interactions. I will talk about our studies on the assembly of the human transcription pre-initiation complex, and about recent results concerning the effect of nucleotide and drug binding on the structure of microtubules.

This talk is part of the MRC LMB Seminar Series series.

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