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Watching Single Molecules

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New physical methods have the potential to reveal details of biological and cellular processes that are undetectable using conventional ensemble measurements. I will firstly introduce scanning ion conductance microscopy, which allows nanoscale imaging of live cells and controlled delivery of molecules to the cell surface. Next I will show how we have developed single molecule fluorescence to detect the interaction of molecules in the test-tube and on cells. Our recent protein aggregates in neurodegenerative disease and the molecular basis of T-cell triggering will be used to show how these methods can provide new biological insights. Lastly I will show how such physical methods can lead to new and powerful technologies by describing the development of Solexa next generation DNA sequencing.

Entry is free to all and free refreshments will be provided.

This talk is part of the ChemSoc - Cambridge Chemistry Society series.

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