It takes two to tango: The cerrebellum simplified into two types of modules with two encoding schemes

Add to your list(s) Download to your calendar using vCal

• Professor Chris de Zeeuw. Erasmus MC, Rotterdam and the Netherands Institute for Neuroscience, Amsterdam
• Monday 03 February 2014, 16:30-18:00
• Hodgkin-Huxley Room, Department of Physiology Development and Neuroscience.

If you have a question about this talk, please contact P.H. Marchington.

1.Gao et al., 2012 Nature Reviews and De Zeeuw et al., 2011 Nature Reviews

2.Detlef, H. H. & De Zeeuw, C. I. et al., J Neuroscience 2013.

3. Detlef, H.H., De Zeeuw, C.I., Jaeger, D., Khodakhan, K., & Person, A.L. 2013 The Neuronal Code(s) of the Cerebellum. The Journal of Neuroscience. 33(45): 17603-17609; doi: 10. 1524/jNeuroscience. 2757-13. 2013.

Abstract Understanding how neurons encode information in sequences of action potentials is of fundamental importance to neuroscience. The cerebellum is widely recognized for its involvement in the coordination of movements, which requires muscle activation patterns to be controlled with millisecond precision. Understanding how cerebellar neurons accomplish such high temporal precision is critical to understanding cerebellar function. Inhibitory Purkinje cells, the only output neurons of the cerebellar cortex, and their postsynaptic target neurons in the cerebellar nuclei, fire action potentials at high, sustained frequencies, suggesting spike rate modulation as a possible code. Yet, millisecond precise spatiotemporal spike activity patterns in Purkinje cells and inferior olivary neurons have also been observed. These results and ongoing studies suggest that the neuronal code used by cerebellar neurons may span a wide time scale from millisecond precision to slow rate modulations, likely depending on the behavioral context.

This talk is part of the Adrian Seminars in Neuroscience series.

This talk is included in these lists:

• Adrian Seminars in Neuroscience
• All Talks (aka the CURE list)
• Biology
• Biology
• Cambridge Neuroscience Seminars
• Cambridge talks
• Chris Davis' list
• Featured lists
• Hodgkin-Huxley Room, Department of Physiology Development and Neuroscience
• Life Science
• Life Sciences
• Life Sciences
• List 1
• ME Seminar
• Neuroscience
• Neuroscience Seminars
• Neuroscience Seminars
• Stem Cells & Regenerative Medicine
• dh539
• kt532's list
• my_list
• other talks

Note that ex-directory lists are not shown.