University of Cambridge > Talks.cam > Madingley Lunchtime Seminars > ‘Developmental programming of cognitive impairment in adulthood: role of chronic fetal hypoxia and oxidative stress’

‘Developmental programming of cognitive impairment in adulthood: role of chronic fetal hypoxia and oxidative stress’

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It is now widely accepted that exposure to sub-optimal environments during early life can increase the risk of disease in later life. Chronic fetal hypoxia is one of the most common complications of high-risk pregnancy. However, compared with cardiovascular, endocrine and metabolic dysfunction, few studies have assessed the effects of fetal hypoxia on cognitive function and cerebral structure at adulthood. Furthermore, interventional studies in this particular field are almost absent. Using various animal models, we have shown that chronic fetal hypoxia programmes cognitive dysfunction and alters cerebral structure at adulthood, and that maternal treatment with antioxidants is an effective therapy against this programming.

This talk is part of the Madingley Lunchtime Seminars series.

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