University of Cambridge > Talks.cam > Genetics Seminar  > COMT: from single nucleotide polymorphism to whole brain function.

COMT: from single nucleotide polymorphism to whole brain function.

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Host: Boris Adyran

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that confer increased risk for schizophrenia. However, the biological mechanisms underlying these associations (and in some cases the roles of the genes in which they located in brain function) are unknown. My research aims to understand links between individual SNPs and whole brain function; much of my work to date has focussed on a functional variant within the catechol-O-methyltransferase (COMT) gene. I will give a brief overview of the current understanding of the genetic architecture of schizophrenia, and will then focus on my research on COMT , as an example of how we might start to move from individual risk SNPs to whole brain function.

This talk is part of the Genetics Seminar series.

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