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Role of Hypoxia-Inducible Factors and Hepcidin in Iron Homeostasis

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Oxygen and iron homeostasis are strongly interrelated. We showed that the Hypoxia Inducible Factors (HIFs), central regulators of mammalian oxygen homeostasis, play a prominent role in the regulation of iron homeostasis. We currently aim to determine the tissue-specific role of hepcidin, the key iron regulatory hormone, in pathophysiological conditions where iron is critically required.

Speaker website: http://cochin.inserm.fr/Departements/emd/equipe-peyssonnaux

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